Skin cells and proteins dating online

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Perhaps the most universally accepted criteria for keratinocyte stem cells are that they are normally slow-cycling (or, perhaps more accurately, rarely cycling) culture conditions to proliferate and to regenerate the tissue; and that they have a high proliferative potential (3–6).

The slow-cycling attribute is particularly important biologically because it conserves the cell's proliferative potential and minimizes DNA replication-related errors.

Like stem cells of other tissues, epidermal stem cells are important because they not only play a central role in homeostasis and wound repair, but also represent a major target of tumor initiation and gene therapy.The slow-cycling stem cells can be identified experimentally as the “label-retaining cells” (LRCs) (7).This is done by long-term labeling of all of the cells with a DNA precursor such as [H]thymidine or bromodeoxyuridine (Brd Urd), followed by a chase period that results in the dilution of the label from all of the rapidly cycling TA cells, but not from the slow-cycling stem cells (7, 8).A schematic diagram of an epidermo-pilosebaceous unit in hair-bearing skin.The unit consists of the epidermis and the hair follicle with its associated sebaceous gland.

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